| Primary Identifier | MGI:7620150 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Iapp |
| Transmission | Germline | Strain of Origin | 129S/SvEv |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A 102 bp part of exon 3 was replaced with the equivalent sequence from a mutated human IAPP cDNA with an A>G (UniProt:P10997:p.S53G) mutation and a loxP site flanked neomycin resistance gene cassette was inserted downstream of the gene. This mutation is associated with premature onset type 2 diabetes in the Asian population. |
