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Allele : Mlkl<em1Pme> mixed lineage kinase domain-like; endonuclease-mediated mutation 1, Pascal Meier
Primary Identifier  MGI:7576921 Allele Type  Endonuclease-mediated
Gene  Mlkl Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  Lysine codon 219 (AAA) in exon 4 was changed to arginine (CGG) (p.K219R) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks ubiquitylation of the residue in the encoded peptide.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Mlkl<K219R>,
  • Mlkl<K219R>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

2 Publication categories





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