| Primary Identifier | MGI:7579164 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Itga2b |
| Transmission | Germline | Strain of Origin | C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 30 was replaced with one where arginine codon 1021 (CGG) was changed to tryptophan (TGG) (p.R1021W), and a loxP site flanked neomycin resistance gene cassette was inserted downstream of the gene. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation is the equivalent of the human p.R995 mutation, associated with macrothrombocytopenia, that renders the encoded peptide constitutively active. |
