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Allele : Disp1<em2Ogd> dispatched RND transporter family member 1; endonuclease-mediated mutation 2, Stacey K. Ogden

Primary Identifier  MGI:7580473 Allele Type  Endonuclease-mediated
Gene  Disp1 Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  CRISPR/cas9-mediated recombination using guide RNAs targeting the extracellular loop 1 created multiple DNA changes resulting in a 3 amino acid substitution starting at position 278 of RRE to AAA. This mutation disrupts the Furin cleavage site in loop 1 compromising processing of the protein.
  • mutations:
  • Nucleotide substitutions,
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Disp1<CS>,
  • Disp1<CS>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories