Primary Identifier | MGI:7580473 | Allele Type | Endonuclease-mediated |
Gene | Disp1 | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | CRISPR/cas9-mediated recombination using guide RNAs targeting the extracellular loop 1 created multiple DNA changes resulting in a 3 amino acid substitution starting at position 278 of RRE to AAA. This mutation disrupts the Furin cleavage site in loop 1 compromising processing of the protein. |