| Primary Identifier | MGI:7627084 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Popdc2 |
| Transmission | Germline | Strain of Origin | B6.Cg-Thy1<a> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Tryptophan codon 188 (TGG) in exon 2 was changed to a stop codon (TAG) (p.W188*) and a an FRT site flanked neomycin resistance gene cassette was inserted into intron 2. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation is the equivalent of the same c.563G>A:p.W188* human mutation associated with familial atrioventricular block (AVB). |
