| Primary Identifier | MGI:7643806 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Ifih1 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Glycine codon 821 (GGT) in exon 13 was changed to serine (AGT) (p.G821S) and a loxP site, a copy of the 5' end of exon 13, a stop codon, poly(A) signal sequence, a neomycin resistance gene cassette and a second loxP site were inserted into intron 12. This is a null allele owing to the premature stop codon. Only after Cre-mediated removal of the duplicate exon 13 sequence and STOP cassette will it express the mutated transcript and peptide. |
