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Allele : Cnn1<em1Mork> calponin 1; endonuclease-mediated mutation 1, Kathleen G Morgan

Primary Identifier  MGI:7797876 Allele Type  Endonuclease-mediated
Attribute String  Hypomorph Gene  Cnn1
Inheritance Mode  Not Specified Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
molecularNote  CRISPR/cas9 mediated recombination using a single guide RNA created a C to G transversion in the first base of the intronic CArG box that disrupts SRF binding. Expression analysis indicates partial loss of expression in visceral smooth muscle containing tissues but full loss of expression in the aorta
  • mutations:
  • Single point mutation
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories