Primary Identifier | MGI:7797876 | Allele Type | Endonuclease-mediated |
Attribute String | Hypomorph | Gene | Cnn1 |
Inheritance Mode | Not Specified | Strain of Origin | C57BL/6J |
Is Recombinase | false | Is Wild Type | false |
molecularNote | CRISPR/cas9 mediated recombination using a single guide RNA created a C to G transversion in the first base of the intronic CArG box that disrupts SRF binding. Expression analysis indicates partial loss of expression in visceral smooth muscle containing tissues but full loss of expression in the aorta |