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Allele : Gt(ROSA)26Sor<tm1(LDLR)Leyma> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Leyuan Ma
Primary Identifier  MGI:8472106 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  C57BL/6N
Is Recombinase  false Is Wild Type  false
molecularNote  A single-copy CAG promoter-driven human LDLR (hLDLR) cDNA expression cassette was targeted into the Gt(ROSA)26Sor safe harbor locus by homologous recombination. A loxP-flanked PGK neo selection marker sits between the CAG promoter and the hLDLR ORF, blocking transcription until Cre recombinase excises it.
  • mutations:
  • Insertion
  • synonyms:
  • hLDLR<fl>,
  • hLDLR<fl>
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Genotypes/models

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Carried By

0 Driven By

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