| Primary Identifier | MGI:1856877 | Allele Type | Chemically induced (other) |
| Gene | Smpd3 | Inheritance Mode | Recessive |
| Strain of Origin | random-bred | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A 1,758 bp deletion encompasses part of intron 8 and most of exon 9. Deletion of the intron 8-exon 9 splice acceptor site leads to the transcription of the undeleted portion of intron 8. A stop codon in the undeleted portion of intron 8 results in the substitution of the last 33 amino acids of the full length allele with 13 amino acids translated from intron 8 sequence. A histidine residue is thus lost that is critical for catalytic activity. |
