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Allele : H2-DMa<tm1Luc> histocompatibility 2, class II, locus DMa; targeted mutation 1, Luc van Kaer

Primary Identifier	MGI:1861933	Allele Type	Targeted
Attribute String	Null/knockout	Gene	H2-DMa
Transmission	Germline	Strain of Origin	129S4/SvJae
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin resistance cassette replaced a 1.5 kb fragment of the gene, encompassing the first and most of the second exon.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
H2-M<0>,
H-2M-,
H2-DM-,
H2-M<0>,
H2-Malpha<->,
H2-DM-,
H2-M-,
H-2M-,
H2-Malpha<->,
H2-M-

earliestPublication:
Martin WD, et al. (1996) H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84(4):543-50

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

48 Publication categories

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